自安本三治等报道,2-苄氧基-5-氟-4(3H)-嘧啶酮(1)具有抗肿瘤活性后,Baba等即以1为中间体,又合成了一系列糖苷类化合物,它们均具有抗肿瘤活性。因此我们进行了1及其同系物的合成研究。文献报道,1可由3在封管中与NaH和Ph CH_2OH反应而得,收率78.2％。 Since Anshin Sanji et al reported that 2-benzyloxy-5-fluoro-4 (3H) -pyrimidinone (1) possesses antitumor activity, Baba et al. Have synthesized a series of glycosides Compounds, all of which have anti-tumor activity. So we did a synthesis study of 1 and its homologs. It has been reported in the literature that 1 can be obtained by reacting 3 with NaH and Ph CH 2 OH in a sealed tube in a yield of 78.2%.