60年代末期,顺铂抗癌作用的发现及其临床应用,促进了人们对金属配合物抗癌活性的研究.顺铂类抗癌剂具有广谱、高效的优点,但也具有较强的毒副作用.顺铂作用于 DNA 分子,在两个相邻鸟嘌呤碱基之间形成双齿链间交联而抑制 DNA 的生物合成.1979年德国的 Kpf 等发现二氯二茂钛(titanocene dichloride,Cp_2TiCl_2,简称 TDC)类化合物具有很好的抗癌活性,由于具有毒性低、抗癌谱广的特点而引起人们的极大兴趣.生物学实验表 In the late 1960s, the discovery of anticancer effect of cisplatin and its clinical application have promoted the research on anticancer activity of metal complexes. Cisplatin anticancer agents have the advantages of broad spectrum and high efficiency, but also have strong toxicity Side effects. Cisplatin on the DNA molecules in the two adjacent guanine bases between the formation of bidentate cross-linked chain to inhibit DNA biosynthesis .1979 Germany Kpf found that titanocene dichloride (titanocene dichloride, Cp_2TiCl_2, referred to as TDC) compounds have good anti-cancer activity, due to its low toxicity, wide spectrum of anti-cancer caused great interest in people’s biological experiment table