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1959年,Selye报道心肌对心脏毒性物质的耐受性可因细胞内低钾和低镁而降低,一旦离子恢复平衡,心肌对心脏毒性物质的耐受性亦恢复正常。冠状动脉的梗阻可造成一个由氧合良好、缺血损害及坏死细胞互相混杂的区域。该区域在生物化学和电活动上是不稳定的,其发展变化取决于许多因毒,包括病变血管的位置、侧枝循环的范围、细胞在损伤以前的状态、内生糖原的储备水平和及时而有效的治疗。早期缺血性改变是可逆的。即使血流停
In 1959, Selye reported that myocardial tolerance to cardiotoxic substances was reduced by intracellular hypokalemia and hypomagnesemia. Once the balance of ions was restored, myocardial tolerance to cardiotoxic substances returned to normal. Coronary artery obstruction can cause a well oxygenated, ischemic damage and necrotic cells mixed with each other. The area is not biochemically and electrically active and its development depends on many factors including the location of the affected vessel, the extent of collateral circulation, the extent to which cells are damaged, the level of endogenous glycogen reserves, and the timeliness And effective treatment. Early ischemic changes are reversible. Even if the blood flow stops