论文部分内容阅读
目的评定理气健脾、熄风化痰法在治疗小儿多发性抽动症肝风内动夹痰证的有效性和安全性。方法将66例符合诊断标准的多发性抽动症患儿随机分为观察组和对照组,每组各33例。试验组采用理气健脾、熄风化痰法,给予止抽片治疗;对照组给予氟哌啶醇口服治疗。两组均以12周为1疗程,共2个疗程。随访病例以研究结束6个月为期。通过耶鲁综合抽动症严重程度量表(YGTSS)观察两组治疗前后总疗效、抽动分类疗效、远期疗效、中医证候改善、不良反应与安全性。结果①试验组和对照组总有效率分别为100%、93.9%,两组中医证候改善率分别为90.9%、84.8%,两组比较差异无统计学意义(P>0.05)。随访后,两组总有效率分别为84.0%、38.1%,远期疗效比较差异有统计学意义(P<0.05)。②试验组运动性抽动疗效优于对照组(P<0.05)。两组发声性抽动疗效、总疗效差异无统计学意义(P>0.05)。③试验组无不良反应,对照组有6例出现不良反应,不良反应发生率为18.2%,两组比较差异有统计学意义(P<0.05)。表明了中医药在治疗该病方面具有显著优势和开发应用前景。结论理气健脾、熄风化痰法是治疗小儿多发性抽动症肝风内动夹痰证的有效方法 。
Objective To evaluate the effectiveness and safety of regulating phlegm and invigorating the spleen and eliminating the wind and resolving phlegm in the treatment of pediatric phlebitis complicated with phlegm syndrome in children with multiple tic disorder. Methods Sixty-six children with multiple tic disorder who meet the diagnostic criteria were randomly divided into observation group and control group, with 33 cases in each group. The experimental group adopted the method of regulating qi and invigorating the spleen, eliminating the wind and phlegm method, giving only the decoction treatment; the control group was treated with haloperidol orally. Two groups were 12 weeks for a course of treatment, a total of 2 courses. Follow-up cases to study the end of 6 months. The Yale tic disorder severity scale (YGTSS) was used to observe the total curative effect before and after treatment, the curative effect of tic by classification, the long-term curative effect, the improvement of TCM syndrome, adverse reactions and safety. Results ① The total effective rates of the experimental group and the control group were 100% and 93.9%, respectively. The improvement rates of TCM syndromes in the two groups were 90.9% and 84.8% respectively. There was no significant difference between the two groups (P> 0.05). After follow-up, the total effective rates of the two groups were 84.0% and 38.1%, respectively. The long-term efficacy was statistically significant (P <0.05). ② The effect of exercise tic in experimental group was better than that in control group (P <0.05). Efficacy of two groups of twitching, the total effect was no significant difference (P> 0.05). ③There was no adverse reaction in the test group. There were 6 adverse reactions in the control group and the incidence of adverse reactions was 18.2%. There was significant difference between the two groups (P <0.05). It shows that traditional Chinese medicine has significant advantages in the treatment of the disease and development and application prospects. Conclusion The method of regulating qi and invigorating the spleen and expelling wind and resolving phlegm is an effective method to treat moving phlegm and phlegm syndrome in children with multiple tic disorder.