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目的:研究正常高值血压患者随血压的升高尿酸与C-反应蛋白(CRP)之间的关系,并探讨其临床意义。方法:184例根据血压分成3组,正常高值血压高组(高值高组)[130～139/85～89mmHg(1mmHg=0.133kPa)]65例,正常高值血压低组(高值低组)(120～129/80～84mmHg)59例,正常血压(正常血压组)(<120/<80mmHg)60例,分别检测血尿酸与CRP。结果:高值低组尿酸与CRP明显高于正常组(P<0.05,P<0.01),高值高组尿酸与CRP明显高于高值低组(P<0.05,P<0.01),并且高值低组与高值高组的尿酸与CRP升高具有相关性,高值高组的相关性又明显高于高值低组,正常血压组两者之间无相关性。结论:尿酸与CRP是高血压的危险因素,两者之间的相互作用加重了高血压的发展。
Objective: To investigate the relationship between uric acid and C-reactive protein (CRP) in hypertensive patients with elevated blood pressure and to investigate its clinical significance. Methods: One hundred and eighty-four patients were divided into three groups according to their blood pressure: 65 patients with normal high blood pressure (high value group) [130 ~ 139/85 ~ 89mmHg (1mmHg = 0.133kPa] (N = 120), normotensive group (n = 120), normotensive group (n = 120) and normotensive group (n = 80) Results: The levels of uric acid and CRP in high value group were significantly higher than those in normal group (P <0.05, P <0.01). Uric acid and CRP in high value group were significantly higher than those in high value group (P <0.05, P <0.01) There was a correlation between uric acid and CRP in the low value group and the high value group, and the correlation between the high value group and the high value low group was no significant difference between the two groups. Conclusion: Uric acid and CRP are risk factors for hypertension, and the interaction between the two may aggravate the development of hypertension.