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目的:探讨肾上腺小细胞神经内分泌癌的起源、诊断要点和治疗方法,以提高对该病的认识。方法:回顾性分析我院收治的一例肾上腺小细胞神经内分泌癌患者,结合国内外文献对本病进行复习总结。结果:本病起源于神经内分泌细胞,临床表现不典型,免疫组化NSE、CgA和Syn可呈阳性,诊断前需排除转移癌,早期发现并手术治疗可能收到良好效果。结论:肾上腺小细胞神经内分泌癌是一种罕见的高度恶性肿瘤,临床表现缺乏特异性,组织学特点和免疫组化神经内分泌标志物是诊断的主要依据,需与肾上腺转移癌相鉴别。可借鉴肺小细胞癌的治疗模式,早期诊断治疗可能是提高其疗效的关键。
Objective: To investigate the origin, diagnosis and treatment of adrenal small cell neuroendocrine carcinoma in order to improve the understanding of the disease. Methods: A retrospective analysis of one case of adrenal small cell neuroendocrine cancer admitted to our hospital, combined with domestic and foreign literature to review the disease summary. Results: The disease originated in neuroendocrine cells. The clinical manifestations were not typical. Immunohistochemical staining of NSE, CgA and Syn was positive. Before the diagnosis, metastatic carcinoma should be excluded. Early detection and surgical treatment may receive good results. Conclusion: Adrenal small cell neuroendocrine carcinoma is a rare and highly malignant tumor. The clinical manifestations are lack of specificity, histological features and immunohistochemical neuroendocrine markers are the main basis for diagnosis, and differentiate from adrenal metastases. Can learn from the treatment of small cell lung cancer model, early diagnosis and treatment may be the key to improve its efficacy.