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目的探讨米非司酮联合甲氨蝶呤在子宫切口瘢痕妊娠中的临床使用效果。方法将本院近年来收治的106例子宫切口瘢痕妊娠患者随机分为观察组与参考组,各为53例,观察组服用米非司酮联合甲氨蝶呤治疗,参考组仅采用甲氨蝶呤治疗,两组患者治疗2周后接受腹腔镜电切术治疗,对两组患者药物治疗成功率、子宫切除率、血HCG转阴时间及平均住院时间进行比较分析。结果观察组药物治疗成功率及子宫切除率分别为92.5%、1.9%,参考组药物治疗成功率及子宫切除率分别为77.4%、17.0%,两组数据比较差异有统计学意义(P<0.05);观察组血HCG转阴时间及平均住院时间均短于参考组(P<0.05)。结论在子宫切口瘢痕妊娠治疗中采用米非司酮与甲氨蝶呤联合治疗,有助于提高手术成功率,减少子宫切除几率,具有显著的临床使用价值。
Objective To investigate the clinical effect of mifepristone combined with methotrexate in uterine incision scar pregnancy. Methods 106 cases of uterine incision scar pregnancy admitted to our hospital in recent years were randomly divided into observation group and reference group, each with 53 cases. The observation group was treated with mifepristone combined with methotrexate. The reference group was treated with methotrexate The two groups of patients underwent laparoscopic electrosurgical treatment after 2 weeks of treatment. The success rate of drug treatment, hysterectomy, blood HCG negative conversion time and average length of stay in the two groups were compared. Results The success rates of treatment and hysterectomy in the observation group were 92.5% and 1.9%, respectively. The success rate of treatment and hysterectomy in the reference group were 77.4% and 17.0%, respectively, with significant difference between the two groups (P <0.05 ). The HCG negative time and average length of hospital stay in the observation group were shorter than those in the reference group (P <0.05). Conclusion The combination of mifepristone and methotrexate in the treatment of uterine incision scar pregnancy can help to improve the success rate of surgery and reduce the chance of hysterectomy, which has a significant clinical value.