论文部分内容阅读
目的比较图像引导放疗(IGRT)与调强放疗(IMRT)两种治疗方式患者的近期疗效和放射性毒性反应,探讨预后影响因素。方法收集52例IGRT的非小细胞肺癌(NSCLC)患者及55例IMRT的NSCLC患者,在满足靶区处方剂量要求的情况下,比较两种治疗方式的近期疗效、放射性毒性反应及影响预后的因素。结果两组治疗后总有效率、控制率差异无统计学意义(P>0.05),IGRT组较IMRT组急性放射性肺炎的发生率低(P<0.05),急性放射性食管炎发生率两组差异无统计学意义(P>0.05)。IGRT 1.0、1.5、2.0年生存率分别为57.7%、35.0%、27.3%,IMRT组分别为50.9%、34.1%、21.8%。两组的中位生存时间分别17.0个月和13.0个月,差异无统计学意义(P>0.05)。结论在NSCLC治疗中,IGRT较LMRT能减轻急性放疗毒性反应的发生,但两种治疗方式对近期疗效的影响差别不明显。
Objective To compare the short-term effects and radiotoxicity of patients with IGRT and IMRT and explore the influencing factors of prognosis. Methods Fifty-two patients with non-small cell lung cancer (NSCLC) from IGRT and 55 patients with IMRT from NSCLC were enrolled in this study. The efficacy, radiotoxicity and prognostic factors were compared between the two treatment regimens . Results There was no significant difference in the total effective rate and control rate between the two groups (P> 0.05). The incidence of acute radiation pneumonitis in IGRT group was lower than that in IMRT group (P <0.05). The incidence of acute radiation esophagitis was no difference between the two groups Statistical significance (P> 0.05). The IGRT rates at 1, 0, 1.5, and 2.0 years were 57.7%, 35.0% and 27.3%, respectively. The IMRT group was 50.9%, 34.1% and 21.8% respectively. The median survival time was 17.0 months and 13.0 months in both groups, with no significant difference (P> 0.05). Conclusion IGRT can reduce the incidence of acute radiotherapy toxicity compared with LMRT in the treatment of NSCLC. However, there is no significant difference between the two treatment methods in the short term efficacy.