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目的:探讨布地奈德粉吸入剂治疗特发性肺间质纤维化的疗效。方法:特发性肺间质纤维化患者30例随机分为观察组(16例)和对照组(14例)。观察组给予布地奈德粉吸入剂治疗,对照组给予口服醋酸泼尼松片治疗,2组疗程均为12周。比较2组治疗前、后症状及肺功能改善情况和不良反应。结果:2组总有效率比较差异无统计学意义(P>0.05);2组治疗后动脉血氧分压、用力肺活量占预计值百分比、一氧化碳弥散能力、单位肺泡容积气体弥散量均较治疗前改善(P<0.05),2组治疗后比较差异无统计学意义(P>0.05);观察组不良反应轻于对照组(P<0.05)。结论:布地奈德粉吸入剂替代口服泼尼松治疗特发性肺间质纤维化疗效满意,不良反应轻,为特发性肺间质纤维化的治疗提供了新的方法和途径。
Objective: To investigate the efficacy of budesonide inhalation in the treatment of idiopathic pulmonary fibrosis. Methods: Thirty patients with idiopathic pulmonary fibrosis were randomly divided into observation group (16 cases) and control group (14 cases). The observation group was treated with budesonide powder inhaler, while the control group was given oral prednisolone acetate tablets. The course of treatment was 12 weeks in both groups. The symptoms and the improvement of pulmonary function and adverse reactions in the two groups before and after treatment were compared. Results: There was no significant difference in the total effective rate between the two groups (P> 0.05). After the treatment, the partial pressure of arterial oxygen, the ratio of forced vital capacity to the predicted value, the diffusing ability of carbon monoxide and the volume of gas per unit volume of alveolar volume were significantly (P <0.05). There was no significant difference between the two groups after treatment (P> 0.05). The adverse reaction in the observation group was lighter than that in the control group (P <0.05). Conclusions: Budesonide powder inhalation is effective in treating Idiopathic Pulmonary Fibrosis with oral prednisone. The adverse reaction is light, which provides a new method and method for the treatment of Idiopathic Pulmonary Fibrosis.