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目的探讨米非司酮联合甲氨蝶呤治疗子宫切口瘢痕妊娠的临床效果。方法选取临颍县人民医院自2010年12月至2011年12月收治的88例子宫切口瘢痕妊娠患者,随机将其分为观察组和对照组,每组44例,对照组单用米非司酮治疗,观察组采用米非司酮联合甲氨蝶呤治疗,对两组患者的治疗总有效率及不良反应发生率、包块消失时间、血人绒毛膜促性腺激素(β-HCG)转阴时间进行对比。结果观察组治疗总有效率为93.18%,对照组为79.55%,观察组明显高于对照组(P<0.05);观察组不良反应发生率明显低于对照组(P<0.05);包块消失时间、血β-HCG转阴时间均明显短于对照组(P<0.05)。结论给予子宫切口瘢痕妊娠患者米非司酮联合甲氨蝶呤治疗可有效提高治疗效果,减少并发症,临床效果显著,值得推广和应用。
Objective To investigate the clinical effect of mifepristone combined with methotrexate in the treatment of uterine incision scar pregnancy. Methods 88 cases of uterine incision scar pregnancy admitted from December 2010 to December 2011 in Linying People’s Hospital were randomly divided into observation group and control group with 44 cases in each group. Ketone treatment, the observation group with mifepristone combined with methotrexate treatment, the two groups of patients with total effective rate and incidence of adverse reactions, mass disappearance of time, blood human chorionic gonadotropin (β-HCG) turn Time contrast. Results The total effective rate was 93.18% in the observation group and 79.55% in the control group, which was significantly higher in the observation group than in the control group (P <0.05). The incidence of adverse reactions in the observation group was significantly lower than that in the control group (P <0.05) Time, blood β-HCG negative time were significantly shorter than the control group (P <0.05). Conclusions Mifepristone combined with methotrexate in patients with uterine incision scar pregnancy can effectively improve the therapeutic effect and reduce the complications, and the clinical effect is significant and worthy of promotion and application.