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目的:探讨胰腺神经内分泌肿瘤(PNEN)临床及病理特点、诊断与治疗方法,为进一步提高该病的认识提供帮助。方法:回顾性分析2011年12月—2013年12月期间安徽医科大学第一附属医院收治的9例PNEN患者的临床及病理资料。结果:9例患者中,男3例,女6例;9例均行B超及CT检查,2例行MRI检查。影像学提示肿瘤位于胰头部3例,颈体部1例,胰尾部1例,体尾部3例,体尾部及肝脏膈面发现结节1例。9例患者有不同的临床症状,胰岛细胞瘤1例,可见明显的低血糖症状,具体表现为头晕、乏力,并伴随有嗜睡、饥饿感、神志不清,其余患者无典型症状;所有患者均接受手术治疗,均经术后病理及免疫组化证实。结论:PNEN发病率低,起病隐匿,常无典型临床症状和体征,确诊主要依靠病理活检及免疫组化,目前手术治疗为其首选的治疗方法。
Objective: To investigate the clinical and pathological features, diagnosis and treatment of pancreatic neuroendocrine tumors (PNEN) and to provide assistance for further understanding of this disease. Methods: The clinical and pathological data of 9 PNEN patients admitted to the First Affiliated Hospital of Anhui Medical University from December 2011 to December 2013 were retrospectively analyzed. Results: Of the 9 patients, 3 were males and 6 were females. Nine cases underwent B-mode ultrasonography and CT and two cases underwent MRI. Imaging findings suggest that the tumor is located in the head of the pancreas in 3 cases, 1 in the neck, 1 in the tail of the pancreas, 3 in the tail of the body, and 1 in the tail of the body and in the nodal surface of the liver. Nine patients had different clinical symptoms, 1 waslet cell tumor, showing obvious symptoms of hypoglycemia, manifested as dizziness, fatigue, accompanied by drowsiness, hunger, confusion, the other patients without typical symptoms; all patients Underwent surgical treatment, confirmed by postoperative pathology and immunohistochemistry. Conclusion: The incidence of PNEN is low, occult onset, often without typical clinical symptoms and signs, the diagnosis depends mainly on pathological biopsy and immunohistochemistry, the current surgical treatment of its preferred treatment.