比较了用灌洗法和用粉碎法处理肺组织提取的两种猪肺泡表面活性物质（ＰＰＳ）对离体灌洗鼠肺顺应性的改善作用。结果：治疗后离体灌洗鼠肺静态肺顺应性恢复程度、压力容量滞后环面积的恢复程度，在对照组为－１．３９％±５．１６％，１．７４％±１８．４８％，在灌洗所得ＰＰＳ（ＬＰＰＳ）组和粉碎法所得ＰＰＳ（ＭＰＰＳ）组分别为９５．８４％±２０．９９％，８８．２±１６．０９％和６４．６７％±１８．２２％，３９．５２％±１６．０９％，均显著高于对照组（Ｐ＜０．０１），ＬＰＰＳ组和ＭＰＰＳ组比较，在前组均大于后组，有显著性差异（Ｐ＜０．０５）．提示：所提取的ＰＰＳ有不同程度的表面恬性，ＬＰＰＳ表面活性优于ＭＰＰＳ。 The effects of two kinds of porcine alveolar surfactant (PPS) extracted from lung tissue by lavage method and pulverization method on lung compliance of isolated lavage mice were compared. Results: After the treatment, the degree of recovery of static pulmonary compliance and the recovery of hysteresis loop area in vitro were -1.39% ± 5.16% and 1.74% ± 18.48% , 95.84% ± 20.99%, 88.2 ± 16.09% and 64.67% ± 18.22% in the PPS (LPPS) group and the PPS (MPPS) 39.52% ± 16.09%, respectively, which were significantly higher than those in the control group (P <0.01). There were significant differences between the LPPS group and the MPPS group in the former group and the latter group (P <0.05) . Hint: The extracted PPS has varying degrees of surface traits, LPPS surface activity is superior to MPPS.