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目的调查贵州省荔波地区人群的肝功能状况及乙型病毒性肝炎感染的情况。方法应用全自动分析仪检测肝功能相关指标以及用酶联吸附试验(ELISA)检测乙肝5项指标并进行分析。结果荔波地区男性肝功能指标异常率大于女性,中年龄组丙氨酸氨基转移酶(ALT)异常率高于低年龄组和高年龄组。HBs Ag、抗-HBs、HBe Ag、抗-HBe、抗-HBc阳性率分别为10.37%、27.53%、0.58%、26.61%、36.98%,抗-HBs阳性率在10岁~19岁组最高(40.63%)。HBV感染模式以模式Ⅰ(5项血清学标志物均阴性)和模式Ⅱ(仅抗-HBs阳性)最多。结论荔波地区男性肝损伤大于女性,而中年龄组肝损伤也大于低年龄组和高年龄组,且低年龄组对HBV感染的抵抗力大于高年龄组。为了阻断HBV的传播,应结合肝功能指标做到早期预防、及时治疗来提高人群的健康状况。
Objective To investigate the liver function and hepatitis B infection in Libo area of Guizhou province. Methods The indexes of liver function were detected by automatic analyzer and the indexes of 5 indexes of hepatitis B were detected by enzyme linked immunosorbent assay (ELISA) and analyzed. Results The abnormal rate of liver function index in Libo area was higher than that in female. The abnormal rate of alanine aminotransferase (ALT) in middle age group was higher than that in lower age group and high age group. The positive rates of HBsAg, anti-HBs, HBe Ag, anti-HBe and anti-HBc were 10.37%, 27.53%, 0.58%, 26.61% and 36.98% respectively. The positive rates of anti-HBs were the highest 40.63%). The pattern of HBV infection was mode I (5 serological markers were negative) and pattern II (anti-HBs positive only). Conclusion Male liver injury in Libo area is greater than that in female, while liver injury in middle age group is also greater than that in low age group and high age group, and resistance in lower age group to HBV infection is higher than that in high age group. In order to block the spread of HBV, liver function should be combined with early prevention, timely treatment to improve the health status of the population.