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化疗中最常见的方法之一是细胞毒药物的应用:这些药物能阻止细胞分裂,杀死细胞。病人常在治疗早期对药物的反应好,但以后变为不敏感。更坏的是,一旦恶性细胞对某种药物不敏感后,对所有的细胞毒药物均有耐药性。如将一些瘤细胞暴露在某些干扰DNA制造的抗生素下,瘤细胞就会对该抗生素和阻止细胞分裂的长春花属生物碱类药物无反应。这些化合物的结构完全不同,唯一的共同点是均为脂溶性。 1985年12月,研究人员在美国国立卫生研究所的工作会议上交换了意见,对肿瘤为什么
One of the most common methods of chemotherapy is the use of cytotoxic drugs: these drugs can prevent cell division and kill cells. Patients often respond to drugs early in treatment, but become insensitive later. What’s worse, once malignant cells are insensitive to a drug, they are resistant to all cytotoxic drugs. If some of the tumor cells are exposed to certain antibiotics that interfere with DNA production, the tumor cells will not respond to the antibiotic and the vinca alkaloids that prevent cell division. The structures of these compounds are completely different. The only common point is that they are all fat-soluble. In December 1985, researchers exchanged opinions at the National Institutes of Health’s work conference on why tumors