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[目的]探讨白介素-1β(IL-1β)、解毒酶谷胱甘肽硫转移酶M1(GSTM1)、DNA错配修复基因(hMLH1)在胃癌中的表达及其与临床病理的关系.[方法]检测200例胃癌患者(胃癌组)和200例胃良性病变患者(对照组)IL-1β、GSTM1、hMLH1基因表达情况,分析其与胃癌临床病理的关系.[结果]胃癌组IL-1β(T/T)、GSTM1缺失、hMLH1低表达显著高于对照组,且差异有显著性(P60岁、肿瘤直径60岁与GSTM1缺失率高相关;肿瘤位置、TNM分期Ⅲ-Ⅳ期与hMLH1低表达相关;logistic回归分析显示,IL-1β(T/T),GSTM1缺失,hMLH1低表达影响胃癌患者5年生存率的危险度(OR)分别为3.124,4.576,7.534,且3种基因存在相互协同作用(P1).[结论]IL-1β(T/T)基因型表达、GSTM1缺失、hMLH1低表达均与胃癌发生发展密切相关,此三种基因存在相互协同作用,患者携带交互作用基因可增加罹患胃癌和死亡的风险.“,”[Objective]To study the expression of IL-1β,GSTM1 and hMLH1 in gastric carcinoma and its relation-ship with clinical pathology.[Methods] Two hundred patients with gastric carcinoma(gastric carcinoma group)and 200 patients with benign gastric lesions(control group)were enrolled in the study.The expression of IL-1β,GSTM1 and hM-LH1 was detected,and its relationship with clinical pathology was analyzed.[Results]The rates of IL-1β(T/T),GSTM1 deletion and low expression of HhMLH1 in the gastric carcinoma group were significantly higher than those in the control group(P 60 years old,tumor diameter 60 years old were much correlated with high rate of GSTM1 deletion.Tumor location and TNM stage Ⅲ ~ Ⅳwere highly correlated with low expression of hMLH1.Logistic regression analysis showed that IL-1β(T/T)(OR = 3.124),GSTM1 deletion(OR = 4.576)and low expression of hM-LH1(OR = 7.534)were risks for the 5-years survival rate of patients with gastric carcinoma,and there was synergistic effect among the three genes(P 1).[Conclusion]Expression of IL-1 βT/T genotype,GSTM1 deletion and low expression of hMLH1 are closely related to the development of gastric carcinoma.There is synergistic effect among the three genes.Carrying genes with interactions will increase the risk of gastric carcinoma and death.