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目的评价抗抑郁药物舍曲林对脑卒中后抑郁患者的治疗效果,及对神经功能康复的影响,为临床治疗提供依据。方法将50例脑卒中患者按入院先后顺序随机分为两组,两组患者均接受脑卒中的常规治疗,包括脱水、降颅压、控制血压、抗凝、活血化瘀及纠正水电解质代谢紊乱,同时预防并发症等。治疗组在常规治疗的基础上同时给予舍曲林50 mg、1次/d口服,连续治疗1个月。结果两组汉密尔顿抑郁量表(HAMD)和神经功能缺损评分标准(改良爱丁堡一斯堪的那维亚卒中量表MESSS)有效率分别为88.0%、84.0%和52.0%、56.0%,两组有效率比较差异有统计学意义(P<0.01)。结论舍曲林可明显改善脑卒中后继发抑郁症的情况,说明舍曲林可以用于脑卒中的治疗。
Objective To evaluate the effect of antidepressant sertraline on patients with post-stroke depression and its effect on neurological rehabilitation, so as to provide basis for clinical treatment. Methods Fifty stroke patients were randomly divided into two groups according to the sequence of hospital admission. Both groups received routine treatment of stroke, including dehydration, intracranial pressure reduction, blood pressure control, anticoagulation, blood circulation and blood circulation and the correction of water and electrolyte metabolism disorders , While preventing complications. The treatment group was given sertraline 50 mg on the basis of routine treatment once a day orally for 1 month. Results The effective rates of HAMD and MESSS were 88.0%, 84.0% and 52.0%, 56.0% in the two groups, respectively The difference in efficiency was statistically significant (P <0.01). Conclusion Sertraline can significantly improve secondary depression after stroke, indicating that sertraline can be used for the treatment of stroke.