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目的提高对系统性红斑狼疮(SLE)自体外周造血干细胞移植风险的认识。方法分析8例SLE自体造血干细胞移植病例的移植相关并发症。结果8例均出现移植后感染,其中真菌、巨细胞病毒和带状疱疹各1例。5例出现心血管并发症,表现为急性左心衰竭、心房颤动和频发室性早搏。没有严重的肝、肾功能损害。结论移植后感染和心血管并发症是SLE自体外周造血干细胞移植后主要移植风险。
Objective To improve the understanding of the risk of systemic peripheral blood stem cell transplantation in patients with systemic lupus erythematosus (SLE). Methods Eight cases of transplant-related complications of SLE autologous stem cell transplantation were analyzed. Results 8 cases of post-transplant infection, including fungi, cytomegalovirus and shingles in 1 case. 5 cases of cardiovascular complications, manifested as acute left heart failure, atrial fibrillation and frequent premature ventricular contractions. No serious liver, kidney damage. Conclusion The posttransplant infection and cardiovascular complications are the major risk of transplantation after SLE autologous peripheral blood stem cell transplantation.