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目的:研究益气养阴方对子宫颈癌细胞基质金属蛋白酶2(MMP2)表达的效应。方法:复制小鼠子宫颈癌U14自发性转移模型,应用免疫组织化学及其组织形态学定量分析方法对MMP2在子宫颈癌中的表达进行研究。结果:益气养阴方组的肺部转移结节较模型组明显减少,并且明显改善化疗对机体的免疫损伤。结论:益气养阴方对肿瘤血管形成有明显抑制作用,降低MMP2的表达可能是其抑制肿瘤血管形成的主要机制之一。
Objective: To study the effect of Yiqi Yangyin Decoction on the expression of matrix metalloproteinase 2 (MMP2) in cervical cancer cells. METHODS: The U14 spontaneous metastasis model of cervical cancer in mice was reproduced. The expression of MMP2 in cervical cancer was studied by immunohistochemistry and histomorphometric quantitative analysis. Results: The metastatic nodules in the lung of the Yiqi Yangyin Decoction group were significantly reduced compared with the model group, and the immune damage to the body was significantly improved by chemotherapy. Conclusion: Yiqi Yangyin Decoction has obvious inhibitory effect on tumor angiogenesis. Decreasing the expression of MMP2 may be one of the main mechanisms of inhibiting angiogenesis.