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Purpose:To compare the corneal thickness of young subjects (aged 18 to 30 years) with moderate and high myopia living in Shantou and Zhengzhou.Methods:One hundred and forty myopic subjects from Shantou (Guangdong,southern China) and 101 from Zhengzhou (Henan,central China)were selected and divided into 2 groups (moderate-myopic group and high-myopic group).The participants were sex-and age-matched.The central corneal thickness (CCT) and thinnest comeal thickness (TCT) were measured by Orbscan and compared between the two groups.Results:In the high-myopic group,CCT (515.47±40.39 μm)and TCT (510.22±40.95 μm) of the Shantou subjects (mean spherical equivalent [SE]-7.56±1.35),were thinner than those of their Zhengzhou counterparts (mean SE -7.47±0.88).In the moderate-myopic group (Shantou mean SE -4.52±0.83;Zhengzhou -4.67± 0.77),CCT and TCT did not differ between the two cities.Conclusion:The corneal thickness of high-myopic eyes may differ between Shantou and Zhengzhou.(Eye Science 2012;27:41-43)