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在产致热原细胞的激活物方面:脂多糖的结构已经阐明,其致热耐受性的免疫机制也已证实,脂多糖通过引起脑组织产生PGE而导致发热也有证明。肽聚糖的结构也已阐明,还证明肽聚糖也可引起致热耐受性,人工合成的肽聚糖的基本亚单位胞壁酰二肽已证明能引起大的发热反应。某些革兰氏阳性细菌的外毒素如葡萄球菌的一种可溶性肠毒素、金色葡萄球
In the production of pyrogen-producing cell activators: The structure of lipopolysaccharide has been elucidated, and its thermo-tolerogenic immune mechanism has also been demonstrated. Lipopolysaccharide has also been shown to induce fever by causing PGE production in brain tissue. The structure of peptidoglycans has also been elucidated. It has also been shown that peptidoglycans also induce thermophilic tolerance. The basic subunit muramyl dipeptide of synthetic peptidoglycans has been shown to cause a large febrile reaction. The exotoxin of some Gram-positive bacteria, such as a soluble enterotoxin of Staphylococcus,