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免疫抑制剂的发现和发展,距今已有三十余年的历史,一九五九年发现抗癌药6—疏基嘌呤能抑制机体的免疫应答,提示可用药物来阻止器官移植后机体的排异反应。一九六○年合成其类似物硫唑嘌呤,并试用于临床,使动物肾移植后一年存活率提高了50%,使人体器官移植外科取得了突破性进展。器官移植外科的迫切需要,极大地推动了免疫抑制剂的研究和发展。目前临床所应用的免疫抑制剂在应用上可分为维持型免疫抑制剂和排异反应治疗型免疫抑制剂,就其
The discovery and development of immunosuppressive agents has been in existence for more than thirty years. In 1959, the anti-cancer drug 6-purine purine was found to inhibit the immune response of the body, suggesting that the available drugs may prevent the organism Rejection. In 1960, the analog of azathioprine was synthesized and used clinically to improve the one-year survival rate of the animal after kidney transplantation by 50%, making a breakthrough in human organ transplantation. The urgent need of organ transplantation surgery has greatly promoted the research and development of immunosuppressive agents. At present, the clinical application of immunosuppressive agents in the application can be divided into maintenance immunosuppressant and rejection reaction therapeutic immunosuppressive agents, on its