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为探讨天然胶原Ⅱ型在RA、SLE等自身免疫性结缔组织病中的临床意义。用ELISA法检测抗Nat Ⅱ IgG、抗dsDNA;采用乳胶增强的速率散射比浊法检测类风湿因子。结果显示71例RA患者中,RF阳性的RA患者的抗Nat Ⅱ IgG结合指数显著高于RF阴性的RA患者。60例SLE患者中,抗dsDNA阳性患者的抗Nat Ⅱ IgG结合指数显著高于抗dsDNA阴性者及RA患者和正常对照组。但抗Nat Ⅱ IgG结合指数的高低与RF及抗dsDNA的含量无显著相关。提示在RA患者中抗Nat Ⅱ IgG阳性的RA患者临床症状明显,X线分期较严重,常有关节骨破坏,表明抗Nat ⅡIgG阳性可预示RA病情的进展程度和严重性。
To explore the clinical significance of natural collagen type Ⅱ in autoimmune connective tissue diseases such as RA and SLE. Anti-Nat Ⅱ IgG and anti-dsDNA were detected by ELISA. Rheumatoid factor was detected by latex-enhanced rate nephelometry. The results showed that among the 71 patients with RA, the anti-Nat Ⅱ IgG binding index of RF-positive RA patients was significantly higher than that of RF-negative RA patients. Among 60 SLE patients, the anti-Nat Ⅱ IgG binding index of anti-dsDNA positive patients was significantly higher than that of anti-dsDNA negative patients and RA patients and normal control group. But the level of anti-Nat Ⅱ IgG binding index had no significant correlation with the content of RF and anti-dsDNA. It is suggested that anti-Nat Ⅱ IgG-positive patients with RA have obvious clinical symptoms, more severe X-ray staging and often destruction of the joint in patients with RA, indicating that anti-Nat Ⅱ IgG positive can predict the progression and severity of RA.