遗传因素可改变许多药物的反应。在正常人群中有个别人,由于对药物代谢速度的遗传差异,可致活性药物或其代谢产物蓄积而引起中毒,或因达不到治疗浓度而使药物失去疗效。有些群体,因为他们体内存在特殊基因,表现对某些药物的敏感性发生改变。有这种遗传紊乱的病人,当其迂到触犯剂(Offending agent)时,会使症状严重恶化,或出现其有害作用(参考表Ⅰ、Ⅱ)。 Genetic factors can change the response of many drugs. In the normal population, there are individuals who, due to the genetic differences in drug metabolism rate, can cause poisoning due to accumulation of active drugs or their metabolites or loss of efficacy due to the lack of therapeutic concentration. Some groups, because of the presence of specific genes in their body, show a change in their sensitivity to certain drugs. Patients who have such a genetic disorder may experience severe deterioration or deleterious effects when they turn to an Offending agent (see Tables I and II).