Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the progressive loss of both upper and lower motor neurons. Most ALS cases are sporadic, but approximately 5–10% of patients have a familial background. To dat
DNA damage has been linked to neuropathology. Diverse DNA damage response (DDR) pathways help preserve DNA integrity in the nervous system during both the developmental and mature stages. Mutations of factors in various signaling pathways responsive to di
Neurovascular dysfunction, as an integral part of Alzheimer\'s disease, may have an important influence on the onset and progression of chronic neurodegenerative processes. The blood- brain barrier (BBB) pathway is one of the main pathways that mediates
The repair of injured tissue is a highly complex process that involves cell proliferation, differentiation, and migration. Cell migration requires the dismantling of intercellular contacts in the injured zone and their subsequent reconstitution in the wou
Efficient strategies for neuroprotection and repair are still an unmet medical need for neurodegenerative diseases and lesions of the central nervous system. Over the last few decades, a great deal of attention has been focused on white matter as a potent
Admission hyperglycemia is an independent predictor, that contributes to hemorrhagic transformation (HT), and worsened functional outcome following reperfusion therapy with tissue plasminogen activator (tPA) in ischemic stroke. Clinical studies have revea
Ischemic stroke is a common and often devastating disease that primarily affects the elderly. Treatment currently consists predominantly of acute thrombolysis and/or thrombectomy to restore blood flow. This reperfusion therapy, however, is only accessible
The neuromuscular junction (NMJ) is the peripheral synapse controlling muscle contraction and coordinated movement in a wide variety of animals. In humans, the mature NMJ is the primary target of morphological disassembly and functional decline in several