作者报告了一例31岁女性患者,因长期肾脏疾病,用皮质类固醇激素和硫唑嘌呤治疗,发生了进行性皮肤溃疡和皮下结节.皮损组织学检查,并经真菌培养证实为隐球菌病.结节及溃疡损害取活体作了组织学检查.结节损害的某一组织坏死区,真皮网状层中有变性细胞及核固缩.周围有孤立的肉芽肿炎性浸润,包括多数组织细胞和巨细胞及无数浆细胞和淋巴细胞.真 The authors reported a 31-year-old woman with progressive skin ulcers and subcutaneous nodules, histological examination of the skin lesions as a result of chronic kidney disease, treatment with corticosteroids and azathioprine, and confirmation of cryptococcosis by fungal culture Nodules and ulcer lesions were taken for histological examination of the tissue necrosis of nodules in a tissue necrosis of the dermal reticular layer of denatured cells and nuclear condensation surrounded by isolated granuloma inflammatory infiltration, including the majority of organizations Cells and giant cells and innumerable plasma cells and lymphocytes