铜是人体必需的营养元素,参与体内许多重要的生化反应。细胞内多种铜转运蛋白和伴侣蛋白参与了铜离子的吸收、转运和清除,形成了一个复杂的铜转运系统。铜转运系统中的铜转运蛋白和/或伴侣蛋白功能异常与多种疾病的发生、发展关系密切。近年来,铜代谢障碍相关疾病越来越受到人们的重视,对铜转运系统相关蛋白的研究也不断深入。 Copper is an essential nutrient for the body and participates in many important biochemical reactions in the body. A variety of copper transporters and chaperones within the cell are involved in the absorption, transport and clearance of copper ions, forming a complex copper transport system. Copper transporter system copper transporter and / or chaperonin dysfunction with a variety of diseases, the development is closely related. In recent years, more and more attention has been paid to the diseases related to copper metabolism disorder, and the research on the related proteins of copper transport system has also been deepened.