为了估价双胍类药物对肝脏碳水化合物代谢的影响,于5例健康男性自愿者,在基础状态和口服buformin 100mg每日2次×5天,继服葡萄糖100g后,对脏器葡萄糖的排出量(SGO)以及净底物的交换情况进行了研究。对照组未用双胍类药物。采用肝静脉插管术取标本测定。吸收后的SGO是147±24(SE)mg/min,服糖后150分钟则增至超过基础值30±2g。双胍服用前没有明显改变糖(131±20mg/ In order to evaluate the effects of biguanides on liver carbohydrate metabolism, five healthy male volunteers were given 100 mg of buformin twice a day for 5 days, followed by 100 g of glucose, SGO) and net substrate exchange were studied. The control group did not use biguanide drugs. Hepatic vein catheterization specimens taken. The absorbed SGO was 147 ± 24 (SE) mg / min and increased to more than 30 ± 2 g at baseline 150 minutes after administration. Biguanide did not change significantly before taking sugar (131 ± 20mg /