Talinopsis frutescens (Anacampserotaceae, a family that is close related to Cactaceae) is a succulent species endemic to North America. The aim of this study was to explore, using Ecological Niche Modeling (ENM), changes in potential distribution ranges considering different climate scenarios: past conditions during the Last Inter Glacial (LIG) and the Last Glacial Maximum (LGM), the present and projections for 2070 (RCP 2.6 to 8.5). A patt of contraction is observed during the LIG, which agrees with other studies focused in species from arid environments. This patt was followed by a migration towards the south during the LGM and a possible recent expansion to the north as is observed in the present scenario. All future projections show the same contraction and fragmentation patts, resulting in three discontinuous areas: the north part of the Chihuahuan Desert, the south-central part of the Mexican Plateau, and the smallest one in the Tehuacán-Cuicatlán Valley. Our projections for future scenarios agree with other studies and support that global climate change tends to alter the current distribution of arid environment species.