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动脉粥样硬化是人类健康的最大杀手之一。巨噬细胞是泡沫细胞形成的主要来源,其在粥样硬化斑块的形成过程中的作用已得到越来越多学者的关注。自噬,作为一种自我保护的细胞代谢途径,与多种疾病有着密切的关系,包括心脑血管疾病、恶性肿瘤、神经退行性疾病、内分泌和代谢性疾病、免疫性疾病等。已有大量研究表明,在动脉粥样硬化的发生发展过程中,巨噬细胞自噬能降低斑块巨噬细胞的胆固醇沉积,促进胆固醇流出,抑制NLRP3炎性小体的组装和激活,揭示了自噬诱导剂可能成为治疗动脉粥样硬化的潜在药物。重点阐述巨噬细胞自噬与动脉粥样硬化的关系,并对自噬相关药物在动脉粥样硬化治疗中的应用进行总结及展望。
Atherosclerosis is one of the biggest killers of human health. Macrophages are the main source of foam cells formation, and their role in the formation of atherosclerotic plaques has received more and more scholars’ attention. Autophagy, as a self-protecting cellular metabolic pathway, is closely related to various diseases including cardiovascular and cerebrovascular diseases, malignant tumors, neurodegenerative diseases, endocrine and metabolic diseases, immune diseases and the like. A large number of studies have shown that during the development of atherosclerosis macrophages can reduce macrophage cholesterol deposition, promote cholesterol efflux and inhibit the assembly and activation of NLRP3 inflammasome, revealing Autophagy-inducing agents may become potential drugs for the treatment of atherosclerosis. It mainly focuses on the relationship between autophagy and atherosclerosis in macrophages and the application of autophagy-related drugs in the treatment of atherosclerosis.