论文部分内容阅读
目的 :探讨代谢综合征患者骨钙素水平与体质量指数、血压、血糖、血脂、胰岛素抵抗指数的相关性。方法 :根据2010年中国2型糖尿病防治指南中代谢综合征的诊断标准,从代谢综合征人群中随机选取50例作为代谢综合征组(A组),从体检中心健康人群中随机选取30例作为对照组(B组),分别测定身高、体质量、空腹血糖(FPG)、甘油三酯(TG)、收缩压(SBP)、舒张压(DBP)、空腹胰岛素(INS)、骨钙素(BGP)水平,分析骨钙素与体质量指数(BMI)、空腹血糖、甘油三酯、胰岛素抵抗指数(HOMA-IR)、血压的相关性。结果 :代谢综合征组(A组)BGP水平明显低于正常对照组(B组),两组比较有统计学意义。Pearson相关分析表明,血清BGP水平与BMI、SBP、DBP、FPG、HOMA-IR呈显著负相关,与TG无明显相关性。多元线性回归分析表明,BMI、FPG、HOMA-IR、SBP是BGP的独立影响因素,BGP是BMI、SBP的独立影响因素。结论 :骨钙素不仅与肥胖、糖代谢有关,而且与血压有关,可以作为代谢综合征的一个预测指标。
Objective: To investigate the correlation between osteocalcin level and body mass index, blood pressure, blood glucose, blood lipid and insulin resistance index in patients with metabolic syndrome. Methods: According to the diagnostic criteria of metabolic syndrome in type 2 diabetes prevention and control guideline in China in 2010, 50 patients were randomly selected from the metabolic syndrome group as the metabolic syndrome group (A group), and 30 patients were randomly selected from the healthy population of the physical examination center The rats in control group (group B) were respectively measured for height, body weight, FPG, TG, SBP, DBP, INS, BGP ), And to analyze the correlation between osteocalcin and body mass index (BMI), fasting blood glucose, triglycerides, insulin resistance index (HOMA-IR) and blood pressure. Results: BGP level in the metabolic syndrome group (group A) was significantly lower than that in the normal control group (group B), and the two groups were statistically significant. Pearson correlation analysis showed that there was a significant negative correlation between serum BGP level and BMI, SBP, DBP, FPG, HOMA-IR and no significant correlation with TG. Multivariate linear regression analysis showed that BMI, FPG, HOMA-IR and SBP were the independent influencing factors of BGP. BGP was an independent influential factor of BMI and SBP. Conclusion: Osteocalcin is not only related to obesity and glucose metabolism, but also to blood pressure, which can be used as a predictor of metabolic syndrome.