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目的:探讨射频消融治疗符合米兰标准的早期肝癌的疗效及预后危险因素。方法:回顾性分析天津医科大学肿瘤医院72例行射频消融治疗的符合米兰标准的早期肝癌患者病例,评估其术后恢复情况,分析复发率、生存率及预后危险因素。结果:72例患者术后并发症轻微且恢复迅速,术后1、2、3年累积复发率分别为12.50%、20.83%和33.33%;1、2、3年累积生存率分别为93.06%、87.50%、79.17%。多因素分析提示肿瘤大小与复发密切相关,肿瘤大小与术前白蛋白水平是影响总生存的独立危险因素。结论:射频消融术治疗符合米兰标准的早期肝癌,近远期效果良好。肿瘤大小是复发的独立危险因素,肿瘤大小与术前白蛋白水平是影响总生存的重要因素。
Objective: To investigate the efficacy and risk factors of radiofrequency catheter ablation in early stage hepatocellular carcinoma meeting Milan criteria. Methods: A retrospective analysis of 72 patients with early-stage liver cancer who underwent radiofrequency ablation in Milan Cancer Hospital of Tianjin Medical University was performed to evaluate the postoperative recovery and analyze the relapse rate, survival rate and risk factors of prognosis. Results: The postoperative complications of 72 patients were slight and rapidly recovered. The cumulative recurrence rates at 1, 2 and 3 years after operation were 12.50%, 20.83% and 33.33% respectively. The cumulative survival rates at 1, 2 and 3 years were 93.06% 87.50%, 79.17%. Multivariate analysis showed that tumor size and recurrence were closely related to tumor size and preoperative albumin levels were independent risk factors affecting overall survival. Conclusion: Radiofrequency catheter ablation is an effective method to treat early stage liver cancer meeting the Milan criteria. Tumor size is an independent risk factor for recurrence. Tumor size and preoperative albumin levels are important factors affecting overall survival.