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目的按中国药典2015年版抑菌效力检查法测定苯酚滴耳液的抑菌效力。方法以金黄色葡萄球菌、铜绿假单胞菌、大肠埃希菌、黑曲霉和白色念珠菌为试验菌株,分别加入苯酚滴耳液中进行微生物的挑战试验,在不同时间点检测样品中微生物的存活情况。结果苯酚滴耳液的抑菌效力符合中国药典2015年版抑菌效力检查法的规定。结论苯酚滴耳液本身已具备充分的抑菌效力,可避免在贮藏和使用过程中发生微生物污染。
Objective To determine the antibacterial activity of phenol ear drops according to the Chinese Pharmacopoeia 2015 edition of Antibacterial Efficacy Test. Methods Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Aspergillus niger and Candida albicans as test strains, were added to the ear drops of phenol solution for microbial challenge test, at different time points to detect microbial Survival. Results The antibacterial efficacy of phenol ear drops conforms to the Chinese Pharmacopoeia 2015 Antibacterial Efficacy Test. Conclusion Phenolic ear drops itself has sufficient antimicrobial efficacy, to avoid microbial contamination during storage and use.