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目的 探讨清开灵注射液 (简称清开灵 )对内毒素性家兔发热的解热机制。方法 复制内毒素性家兔发热模型 ,以数字温度计测量结肠的温度 ,用放免法测定下丘脑中的IL 1β和cAMP、脑脊液中的cAMP、腹中隔区 (VSA)的精氨酸加压素 (AVP)的含量。结果 ①清开灵对内毒素性发热家兔有显著性的解热效应 (P <0 0 1) ;②明显抑制下丘脑IL 1β及cAMP的生成 (P <0 0 1) ;③显著降低脑脊液 (CSF)中cAMP及腹中隔区AVP的含量 (P <0 0 1)。结论 清开灵对内毒素性发热的重要解热机制可能与抑制内生致热原和中枢发热介质的生成 ,促进解热物质的释放有关
Objective To investigate the antipyretic mechanism of Qingkailing injection (Qingkailing) for endotoxin-induced fever in rabbits. Methods The endotoxin febrile rabbit fever model was reproduced. The temperature of the colon was measured with a digital thermometer. IL 1β and cAMP in the hypothalamus, cAMP in the cerebrospinal fluid, and arginine vasopressin in the abdominal septal region (VSA) were determined by radioimmunoassay. (AVP) content. Results 1Qingkailing had a significant antipyretic effect on endotoxin-induced fever in rabbits (P <0 01); 2 significantly inhibited the production of IL-1β and cAMP in the hypothalamus (P <0 01); 3 significantly decreased CSF ( CSF) and AVP content in abdominal septum (P <0 01). Conclusion The important antipyretic mechanism of Qingkailing on endotoxin-induced fever may be related to the inhibition of endogenous pyrogens and central heat-generating mediators and promote the release of antipyretic substances.