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目的:观察三乙醇胺乳膏预防中晚期宫颈癌患者放射治疗致急性放射性皮肤损伤的临床疗效。方法:将84例需放射治疗的中晚期宫颈癌患者采用随机数字表法随机分为2组,用药组42例在第1次放射治疗后给予三乙醇胺乳膏涂抹上至脐平面、下至大腿上1/3、两侧至腋中线区域及臀部、骶尾部皮肤(包括会阴部、肛周及腹股沟区皮肤),对照组42例只做常规放射治疗宣教和健康教育。结果:两组皮肤损伤发生率均为100%。重度皮肤损伤(3、4级),用药组为9.6%(4/42),对照组为42.9%(18/42),两组差异具有统计学意义(P<0.05)。在照射剂量40Gy以前出现皮肤损伤,用药组为28.6%(12/42),对照组为95.2%(40/42)。两组差异具有统计学意义(P<0.05)。结论:三乙醇胺乳膏能有效降低中晚期宫颈癌放疗患者皮肤损伤的程度,提高皮肤的耐受性,推迟损伤出现的时间,保证放射治疗的顺利进行。
Objective: To observe the clinical efficacy of triethanolamine cream in preventing radiation-induced acute radiation-induced skin lesions in patients with advanced cervical cancer. Methods: Eighty-four patients with advanced cervical cancer requiring radiotherapy were randomized into two groups randomly. Twenty-two patients in the medication group were treated with triethanolamine cream on the umbilicus plane after the first radiotherapy, On the 1/3, both sides to the axillary region and buttocks, sacrococcygeal skin (including the perineum, perianal and groin skin), the control group of 42 cases only conventional radiotherapy education and health education. Results: The incidence of skin lesions in both groups was 100%. Severe skin lesions (grade 3 and 4), medication group was 9.6% (4/42), control group was 42.9% (18/42), the difference between the two groups was statistically significant (P <0.05). Skin lesions occurred at a dose of 40 Gy prior to irradiation, with 28.6% (12/42) in the drug-treated group and 95.2% (40/42) in the control group. The difference between the two groups was statistically significant (P <0.05). Conclusion: Triethanolamine cream can effectively reduce the degree of skin damage in radiotherapy patients with advanced cervical cancer, improve skin tolerance, delay the occurrence of injury, and ensure the smooth progress of radiation therapy.