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目的:探讨多西他赛、吉西他滨和奥沙利铂联合(DOG方案)治疗难治性乳腺癌近期疗效和毒副反应。方法:7例病理证实的晚期乳腺癌患者均接受过多西他赛分别联合阿霉素、顺铂,吉西他滨+顺铂方案,化疗后进展或无好转,再给予DOG方案化疗观察临床疗效。结果:5例达到部分缓解,1例稳定,1例进展,有效率71.42%,临床获益率85.71%。结论:DOG方案是耐受蒽环类、紫杉类药物的难治性乳腺癌有效方案之一,且毒副反应可以耐受,值得临床进一步应用观察。
Objective: To investigate the short-term effects and side effects of docetaxel, gemcitabine and oxaliplatin combined with DOG regimen in the treatment of refractory breast cancer. Methods: Seven patients with pathologically proved advanced breast cancer received docetaxel combined with doxorubicin, cisplatin and gemcitabine plus cisplatin respectively. After chemotherapy, the patients progressed or did not improve. The clinical efficacy of DOG regimen was observed. Results: 5 cases achieved partial remission, 1 case was stable, 1 case progressed. The effective rate was 71.42%. The clinical benefit rate was 85.71%. Conclusion: The DOG regimen is one of the effective regimens for breast cancer refractory to anthracyclines and taxanes, and its side effects can be tolerated. It is worth further clinical observation.