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目的探讨益生菌(复合乳酸菌胶囊,聚克)治疗亚临床肝性脑病(SHE)对其转归的影响及机制。方法随机将60例经数字连接试验(NCT)、数字符号试验(DST)和/或体感诱发电位(SEP)检查异常的SHE患者分配入治疗组、对照组各30例。治疗组给予聚克和复合维生素B治疗8周,对照组仅给予复合维生素B治疗8周。两组均在第4、8周末随访,作血氨、肝功能、SEP、NCT、DST,并观察肝性脑病(HE)的发病率。结果治疗后4周两组间比较在肝功能、血氨、SEP各波潜伏期差异均无统计学意义(P>0.05),但在NCT、DST、HE发病率差异均有统计学意义(P<0.05);第8周治疗组血氨较对照组有改善(P<0.05)。结论益生菌治疗能降低血氨,改善智力测验和降低HE发病率。
Objective To investigate the effect and mechanism of probiotics (compound lactic acid bacteria capsule and polyketide) on the outcome of subclinical hepatic encephalopathy (SHE). Methods Sixty SHE patients with abnormalities of digital signage test (NCT), digital sign test (DST) and / or somatosensory evoked potential (SEP) were randomly assigned to treatment group and control group. The treatment group was given polyglucosamine and vitamin B for 8 weeks, while the control group only given vitamin B for 8 weeks. Blood ammonia, liver function, SEP, NCT and DST were observed at the 4th and 8th week in both groups. The incidence of hepatic encephalopathy (HE) was also observed. Results There was no significant difference in the latency of liver function, blood ammonia and SEP between the two groups at 4 weeks after treatment (P> 0.05), but the differences in the incidence of NCT, DST and HE were statistically significant (P < 0.05). In the 8th week, the blood ammonia in the treatment group was better than that in the control group (P <0.05). Conclusion Probiotics can reduce blood ammonia, improve mental tests and reduce the incidence of HE.