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Sarnoff等于1944年首次应用血管扩张剂治疗肺水肿。目前已作为心力衰竭的一种治疗方法。心衰的基本成因是左心室收缩力减退。它可以直接由心肌损害(如缺血性心脏病)或者由于慢性压力或容量负荷过度(如高血压、瓣膜病)所引起。心脏收缩力减退的早期反应是心室扩张,继之交感神经张力反射性增高和血管紧张素分泌增加。临床表现为心率加速,心肌收缩力和外周血管阻力增高。目的在于保证重要脏器(心、脑)的血流灌注。对于衰竭的心肌长期应用强心药物是有利或是有弊,文献中的看法并不一致。变应性药物如多巴胺(DoPamine)和多巴酚丁胺(dobutamine)只宜短期
Sarnoff is equal to the first application of vasodilators in 1944 for the treatment of pulmonary edema. Has now been used as a treatment for heart failure. The basic cause of heart failure is left ventricular contractility. It can be caused directly by myocardial damage (such as ischemic heart disease) or due to chronic stress or volume overload (such as hypertension, valvular disease). The early response to diminished cardiac contractility is ventricular dilatation, followed by increased sympathetic tone reflex and increased angiotensin secretion. Clinical manifestations of accelerated heart rate, myocardial contractility and peripheral vascular resistance increased. The purpose is to ensure that blood vessels of important organs (heart, brain) perfusion. The long-term use of cardiotonic drugs in failing myocardium is good or bad, and the opinions in the literature are not consistent. Allergic drugs such as doPamine and dobutamine should only be short term