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目的探讨盐酸去甲乌药碱作为心脏负荷试验药物在放射性核素心肌灌注显像检测冠状动脉病变中的价值。方法13只中华小型猪,于冠状动脉左前降支近中段放置Ameroid动脉环,造成慢性冠状动脉狭窄模型,3周后,分别进行盐酸去甲乌药碱和多巴酚丁胺药物负荷试验,静态心肌SPECT显像。结果应用盐酸去甲乌药碱和多巴酚丁胺负荷试验放射性核素心肌显像,检测冠心病的敏感性均为92%,而盐酸去甲乌药碱和多巴酚丁胺负荷显像之间图像评分(9.9±8.5和9.4±8.6,P=NS)和定量分析(0.68±0.12和0.68±0.15,P=NS)均没有差别,两者的图像评分有很高的一致性(kappa=0.849,P<0.0001)。结论本研究表明,与多巴酚丁胺相似,盐酸去甲乌药碱可用于药物负荷试验心肌灌注显像检测冠状动脉狭窄和心肌缺血。
Objective To investigate the value of norfloxacin hydrochloride as a cardiac load testing drug in the detection of coronary artery lesions by radionuclide myocardial perfusion imaging. Methods Thirteen Chinese miniature pigs were randomly divided into two groups: Ameroid arterial rings in the proximal middle part of the left anterior descending coronary artery, resulting in a model of chronic coronary artery stenosis. Three weeks later, the drug loading tests were performed on norvanodamine and dobutamine hydrochloride respectively. Myocardial SPECT imaging. Results The sensitivity of norcolamine hydrochloride and dobutamine stress test radionuclide myocardial imaging in detecting coronary heart disease were 92%, while the norfentanil hydrochloride and dobutamine stress imaging (9.9 ± 8.5 and 9.4 ± 8.6, P = NS) and quantitative analysis (0.68 ± 0.12 and 0.68 ± 0.15, P = NS), respectively. There was high agreement between the two images (kappa = 0.849, P <0.0001). Conclusions This study shows that, similar to dobutamine, norfloxacin hydrochloride can be used in drug loading tests for myocardial perfusion imaging to detect coronary artery stenosis and myocardial ischemia.