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血管紧张素Ⅱ（ＡｎｇⅡ）为肾素血管紧张素系统（ＲＡＳ）的重要生物活性肽，除参与正常血管张力、维持水盐平衡调节外，由局部ＲＡＳ产生的ＡｎｇⅡ还参与了局部组织细胞的功能及生长的调节。并在某些心血管疾病如高血压、心肌肥厚、充血性心衰、缺血性心肌病及肾功能不全等病理过程发生发展中起着重要作用。ＡｎｇⅡ主要通过激活特异性受体而发挥其生物学效应。它有ＡＴ１和ＡＴ２两个亚型。ＡＴ１受体能被非肽类ＡｎｇⅡ受体拮抗剂Ｌｏｓａｒｔｅｎ特异性阻断，而ＡＴ２受体能被其拮抗剂ＰＤ１２３１７７、ＰＤ１２３３１９及ＣＧＰ４２１１２Ａ等特异性阻断。两种受体在不同组织或同一组织的不同细胞介导ＡｎｇⅡ复杂的生物学效应。
AngII is an important bioactive peptide of renin-angiotensin system (RAS). AngⅡ, which is produced by local RAS, participates in the function of local tissue cells in addition to being involved in normal vascular tone and maintaining water and salt balance. And the regulation of growth. And play an important role in the development of certain cardiovascular diseases such as hypertension, cardiac hypertrophy, congestive heart failure, ischemic cardiomyopathy and renal insufficiency. Ang II exerts its biological effects mainly through the activation of specific receptors. It has two subtypes AT1 and AT2. AT1 receptor can be specifically blocked by Losarten, a non-peptide angiotensin II receptor antagonist, while AT2 receptor can be specifically blocked by its antagonists PD123177, PD123319 and CGP42112A. The two receptors mediate the complex biological effects of Ang II in different cells of different tissues or in the same tissue.