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目的:探讨鼻咽癌患者放疗后全脑灰质体积的改变情况。方法:对20例接受过放射治疗的鼻咽癌患者及16例已确诊而未行放射治疗的鼻咽癌患者,进行全脑高分辨率T1WI扫描,采用基于体素形态测量学(VBM)方法,分析鼻咽癌治疗组与未治疗组脑灰质体积变化的差异。结果:与未治疗组比较,鼻咽癌治疗组双侧颞中回、左侧额上回、左侧枕下叶脑灰质体积显著减少。结论:鼻咽癌放疗后部分脑区脑灰质体积减少,VBM可早期发现常规MRI未显示的异常。
Objective: To investigate the changes of whole brain gray matter volume after radiotherapy in patients with nasopharyngeal carcinoma. Methods: Twenty patients with nasopharyngeal carcinoma who underwent radiotherapy and 16 patients who had been diagnosed without radiotherapy were enrolled in this study. High-resolution T1WI scan of the whole brain was performed. Vital morphometry (VBM) , Analysis of nasopharyngeal carcinoma treatment group and untreated group of gray matter volume changes in the difference. Results: Compared with the untreated group, the volume of the left suboccipital lobe and gray matter in the bilateral medial temporal gyrus, the left superior frontal gyrus and the left inferior cerebral cortex significantly decreased. Conclusion: Cerebral gray matter volume decreased after radiotherapy in nasopharyngeal carcinoma, and abnormalities of VBM were not found in conventional MRI.