PTEN(也称MMACl或TEP1)是1997年克隆到的一种新的肿瘤抑制基因,它定位于10q23.3,是迄今发现的第一个具有特异性磷酸酶活性的抑癌基因[1]。研究表明,在原发性乳腺癌、子宫内膜癌、恶性胶质瘤等大量的肿瘤成分中有该基因的突变和失活,近年来在头颈部肿瘤中也发现其有异常表达。它在细胞的生长发育、信号转导和细胞凋亡中起重要作用,自发现以来,引起学者们的广泛关注。现就PTEN与头颈 PTEN (also known as MMAC1 or TEP1) is a new tumor suppressor gene cloned in 1997 and located at 10q23.3. It is the first tumor suppressor gene with specific phosphatase activity discovered to date [1]. Studies have shown that in a large number of primary breast cancer, endometrial cancer, glioblastoma and other tumor components of the mutation and inactivation of the gene in recent years, head and neck cancer also found abnormal expression. It plays an important role in cell growth and development, signal transduction and apoptosis. Since its discovery, it has drawn wide attention of scholars. Now PTEN and head and neck