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目的 探讨E钙粘蛋白 catenin粘附系统在人非小细胞肺癌细胞系中的表达。 方法 采用免疫组织化学和RT PCR两种方法分别从蛋白及mRNA两个水平分析E钙粘蛋白、α catenin、β catenin在 7种人非小细胞肺癌细胞系中的表达情况。 结果 每个细胞系至少出现 1个、两个或多个E钙粘蛋白 /catenin复合体成分的表达异常。 结论 E钙粘蛋白、α catenin和 β catenin的蛋白及mRNA异常表达与人非小细胞肺癌有关。
Objective To investigate the expression of E-cadherin catenin adhesion system in human non-small cell lung cancer cell lines. Methods The expressions of E-cadherin, α catenin and β catenin in seven human non-small cell lung cancer cell lines were analyzed by immunohistochemistry and RT PCR respectively. As a result, at least one occurs per cell line and the expression of two or more E-cadherin / catenin complex components is abnormal. Conclusion The abnormal expressions of E-cadherin, α catenin and β catenin in human non-small cell lung cancer are related to the abnormal expression of E-cadherin, α catenin and β catenin.