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目的 :探讨血浆一氧化氮 (NO)和内皮素 (ET)水平在突发性聋 (突聋 )发病过程中的作用。方法 :对32例突聋患者用硝酸还原酶法测定血浆NO ,用放射免疫法测定血浆ET。结果 :突聋组血浆NO显著降低 ,ET显著升高 ,与正常对照组相比较 ,突聋组血浆NO显著降低 (P <0 .0 1) ,ET显著升高 (P <0 .0 1) ;突聋治疗前与治疗后血浆NO、ET之间差异有显著性意义 (P <0 .0 1) ;治疗有效者与无效者血清NO、ET水平的差异也有显著性意义 (P <0 .0 1)。结论 :在突聋发作过程中 ,血浆NO和ET的含量显著变化 ,可能促进了疾病的发生和发展
Objective: To investigate the role of plasma nitric oxide (NO) and endothelin (ET) in the pathogenesis of sudden deafness (sudden deafness). Methods: Plasma NO was measured by nitrate reductase in 32 patients with sudden deafness, and plasma ET was measured by radioimmunoassay. Results: Compared with the normal control group, NO in the sudden deafness group was significantly lower than that in the normal control group (P <0.01), NO was significantly decreased (P <0.01) (P <0.01). There was also significant difference between NO and ET levels in patients with sudden deafness before and after treatment (P <0.01). There was also significant difference in serum NO and ET levels between treated and ineffective persons (P <0.01). 0 1). Conclusion: During the process of sudden deafness, the content of plasma NO and ET changes significantly, which may promote the occurrence and development of the disease