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本文对60名80岁以上的老年人,进行外周血淋巴细胞分裂指数、染色体众数和自然畸变率的检查,并以22名健康中年人对照。结果指出:老年组外周血淋巴细胞的分裂指数较对照组显著下降,二倍体细胞减少,非整倍体增加,特别是亚二倍体细胞显著增加,染色体的自然畸变率也有显著差异。老年组男女间均无差异,由此看出人的衰老因素十分复杂,而外周血淋巴细胞的分裂指数,染色体众数和自然畸变率的改变,可作为研究衰老的微观指标之一。
This article 60 elderly people over the age of 80, the index of peripheral blood lymphocyte division, chromosome number and natural aberration rate of examination, and 22 healthy middle-aged controls. The results showed that the index of division of peripheral blood lymphocytes in elderly group decreased significantly compared with the control group, the number of diploid cells decreased, the number of aneuploidy increased, especially the sub-diploid cells increased significantly, and the natural aberration rate of chromosomes also had significant difference. There was no difference between male and female elderly people, which shows that the factors of human aging are very complicated. However, the change of lymphocyte dividing index, chromosome number and natural aberration of peripheral blood can be used as one of the micro-indexes for studying aging.