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目的了解成年艾滋病抗病毒治疗患者生存状况及其影响因素,为改善艾滋病患者生存状况提供参考依据。方法收集2006年9月—2010年9月在宁夏医科大学总医院接受抗病毒治疗的152例≥18周岁成年艾滋病患者病历资料,分析其在观察期间的生存状况,并采用多因素Cox比例风险回归模型分析影响患者生存状况的影响因素。结果 2015年9月30日随访截止时,152例成年艾滋病抗病毒治疗患者中仍在治疗102例(67.11%),失访7例(4.61%),转诊10例(6.58%),停药5例(3.29%),死亡28例(18.42%);28例死亡患者中,死于艾滋病者21例(75.00%),因其他因素致死者7例(25.00%);21例死于艾滋病患者中,抗病毒治疗<1年死亡11例(52.38%),2~3年死亡7例(33.33%),4~5年死亡3例(14.29%)。多因素Cox比例风险回归分析结果显示,年龄≥30岁、WHO临床分期Ⅲ期以上、感染途径为异性和同性性途径感染是影响成年艾滋病抗病毒治疗患者生存状况的危险因素;CD4~+细胞计数>200个/μL和抗病毒治疗方案为≥2种抗菌药物联合治疗是影响成年艾滋病抗病毒治疗患者生存状况的保护因素。结论年龄、CD4~+细胞计数、WHO临床分期、抗病毒治疗方案和感染途径是成年艾滋病抗病毒治疗患者生存状况的主要影响因素。
Objective To understand the survival status of AIDS patients and its influencing factors, and to provide a reference for improving the living conditions of AIDS patients. Methods The clinical data of 152 AIDS patients aged 18 years or older who received antiretroviral therapy at the General Hospital of Ningxia Medical University from September 2006 to September 2010 were collected and their survival status during the observation period was analyzed. Multivariate Cox proportional hazards regression Model analysis of factors affecting the survival of patients. Results As of September 30, 2015, 102 patients (67.11%) were still under treatment with 152 adult AIDS patients, 7 (4.61%) were lost to follow-up, 10 (6.58% Among the 28 deaths, 21 (75.00%) died of AIDS, 7 died of other causes (25.00%), and 21 died of AIDS Among them, 11 cases (52.38%) died of antiviral therapy in 1 year, 7 cases (33.33%) died in 2 to 3 years and 3 cases (14.29%) died in 4 to 5 years. Multivariate Cox proportional hazards regression analysis showed that age ≥30 years old, WHO clinical stage Ⅲ or more, the way of infection is heterosexual and homosexual infection is a risk factor affecting the survival of adult patients with antiviral therapy; CD4 ~ + cell count > 200 / μL and antiviral therapy ≥2 combinations of antimicrobial agents are protective factors affecting the survival of adult patients with antiviral therapy. Conclusions Age, CD4 ~ + cell count, WHO clinical stage, antiviral treatment and route of infection are the main influencing factors in the survival of adult AIDS patients.