报道了一种利用DNA网络为模板原位合成金纳米颗粒的方法。利用AuCl4-阴离子和DNA碱基间的配位作用,使AuCl4-结合到预先制备好的DNA网络模板上,然后还原AuCl4-,在DNA模板上原位合成具有良好分散性的金纳米颗粒。通过在水溶液中以DNA为稳定剂的金纳米颗粒的成功合成,间接证明了DNA网络上合成的颗粒物为金纳米颗粒。原子力显微镜表征说明,DNA网络的疏密程度以及还原时间对金纳米颗粒的尺寸影响甚小,纳米颗粒平均粒径为2～3 nm。报道的表面原位合成金纳米颗粒的方法在纳米电子器件以及电化学催化等领域具有良好的应用前景。 A method of in situ synthesis of gold nanoparticles using a DNA network as a template was reported. The coordination between AuCl4- anion and DNA base was used to bind AuCl4- to pre-prepared DNA network template, then AuCl4- was reduced to synthesize gold nanoparticles with good dispersibility in situ on DNA template. The successful synthesis of gold nanoparticles with DNA as a stabilizer in aqueous solution indirectly proves that the synthesized particles on the DNA network are gold nanoparticles. Atomic force microscopy characterization showed that the density of DNA network and the reduction time had little effect on the size of the gold nanoparticles, and the average diameter of the nanoparticles was 2 ~ 3 nm. The reported method of in situ synthesis of gold nanoparticles has good application prospects in the fields of nanoelectronic devices and electrochemical catalysis.