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目的：采用乌梢蛇腹部皮肤研究ｐＨ，药物浓度和月桂氮酮对二氢埃托啡（ＤＨＥ）体外透皮作用的影响。方法：采用改良Ｆｒａｎｚ直立式释放池对ＤＨＥ的体外释放作了研究。有效释放面积为２．５ｃｍ２，按设定的时间间隔取样直至２４ｈ，取样量为１００μｌ，并用液闪法分析ＤＨＥ透过量。结果：ｐＨ对ＤＨＥ渗透的影响很复杂，在ｐＨ３和９透皮流率明显快于ｐＨ５和７。不同浓度ＤＨＥ的透皮流率也不同，在实验选择的ＤＨＥ浓度范围内，ＤＨＥ的透皮流率与ＤＨＥ浓度成正比。月桂氮酮对ＤＨＥ的渗透有很强的促进作用。结论：通过乌梢蛇皮腹部皮肤研究了不同因素对ＤＨＥ透皮作用影响，发现ｐＨ、药物浓度和促渗剂对ＤＨＥ的透皮作用影响复杂。其结果为进一步研究ＤＨＥ透皮给药系统提供了有益的参考。
OBJECTIVE: To study the effects of pH, drug concentration and lavone on the transdermal effect of dihydroetorphine (DHE) on the skin of the snakebite. METHODS: In vitro release of DHE was studied using a modified Franz upright release cell. Effective release area of 2.5cm2, sampling at set intervals until 24h, sampling volume of 100μl, and the DHE transmission through the liquid scintillation method. Results: The effect of pH on DHE permeation was complex, with transdermal flow rates significantly faster at pH 3 and 9 than at pH 5 and 7. Different concentrations of DHE transdermal flow rate is also different, DHE concentration range in the experiment selected, DHE transdermal flow rate and DHE concentration is proportional to. Diazepam on the DHE penetration has a strong role in promoting. CONCLUSION: The effects of different factors on the dermal penetration of DHE were studied through the skin of the snake skin. It was found that the effects of pH, drug concentration and penetration enhancers on the dermal penetration of DHE were complex. The results provide a useful reference for further study of DHE transdermal delivery system.