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腺病毒(Ad)基因组E_1、E_3、以及E_4区和右侧端插入性末端重复(ITR)之间的区段,均存在外源基因插入位点。本文论述了外源保护性免疫原基因插入Ad基因组上述不同位点构建各类重组疫苗载体的研究进展。
The adenovirus (Ad) genome E_1, E_3, and the segment between the E_4 region and the right-hand end insertion repeats (ITRs) all have foreign gene insertion sites. This article discusses the progress of research on the construction of various recombinant vaccine vectors by inserting the exogenous protective immunogen genes into the above Ad Site of the Ad genome.