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目的:探讨慢性肺心病患者急性发作期血清中一氧化氨(NO)、一氧化氮合成酶(NOS)、超氧化物歧化酶(SOD)和肿瘤坏死因子(TNF-α)的变化及意义。方法:以58例慢性肺心病患者和50例健康人为研究对象,分别应用化学法和放射免疫法测定血清NO、NOS、SOD及TNF-α水平。结果:肺心病组患者血清中SOD水平较健康人明显下降(P<0.01),而NO、NOS和TNF-α水平比健康人明显增高(P<0.01)。肺心病组患者血清NO、NOS水平上升,血清TNF-α水平也随之上升,呈明显的正相关(r=0.6162,0.6564,P<0.01);而SOD与TNF-α之间无相关性(r=0.2135,P>0.05)。结论:NO、NOS、SOD及TNF-α水平变化参与了肺心病的发生、发展过程。
Objective: To investigate the changes and significance of serum nitric oxide (NO), nitric oxide synthase (NOS), superoxide dismutase (SOD) and tumor necrosis factor (TNF-α) in acute episode of chronic cor pulmonale. Methods: Fifty-eight patients with chronic cor pulmonale and 50 healthy subjects were selected as experimental subjects. The serum levels of NO, NOS, SOD and TNF-α were measured by radioimmunoassay. Results: The levels of serum SOD in patients with pulmonary heart disease were significantly lower than those in healthy people (P <0.01), while the levels of NO, NOS and TNF-α were significantly higher than those in healthy people (P <0.01). Serum levels of NO and NOS in patients with pulmonary heart disease increased, and serum TNF-α levels also increased significantly (r = 0.6162,0.6564, P <0.01), while there was no correlation between SOD and TNF-α r = 0.2135, P> 0.05). Conclusion: The changes of NO, NOS, SOD and TNF-α are involved in the occurrence and development of pulmonary heart disease.