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Objective Due to their lower risk for induction of resistance,antimicrobial peptides with selective anticancer effect could be developed into a new generation of anticancer drugs.We conjugated an antimicrobial peptide with tumor-targeting peptides (TMTP1) to explore whether it has inhibiting effect on the progression and metastasis of transplanted prostate cancer and gastric cancer in nude mice.Methods Subcutaneously transplanted human prostate cancer and orthotopically transplanted human gastric cancer in nude mice were prepared.50
Objective Due to their lower risk for induction of resistance, antimicrobial peptides with selective anticancer effect could be developed into a new generation of anticancer drugss.We conjugated an antimicrobial peptide with tumor-targeting peptides (TMTP1) to exploring whether it has inhibiting effect on the progression and metastasis of transplanted prostate cancer and gastric cancer in nude mice. Methods Subcutaneously transplanted human prostate cancer and orthotopically transplanted human gastric cancer in nude mice were prepared. 50